© 2015, Springer-Verlag Berlin Heidelberg.Genetic studies have identified single nucleotide polymorphisms associated with the risk of prostate cancer. It remains unclear whether such genetic variants are associated with disease aggressiveness. The NCI-SPORE Genetics Working Group retrospectively collected clinicopathologic information and genotype data for 36 SNPs which at the time had been validated to be associated with PC risk from 25,674 cases with PC. Cases were grouped according to race, Gleason score and aggressiveness. Statistical analyses were used to compare the frequency (...) of the SNPs between different disease cohorts. After adjusting for multiple testing, only PC-risk SNP rs2735839 was significantly and inversely associated with aggressive and high-grade disease in European men. Similar associations with aggressive and high-grade disease were documented in African-American subjects. The G allele of rs2735839 was associated with disease aggressiveness even at low PSA levels in both European and African-American men. Our results provide further support that a PC-risk SNP rs2735839 near the KLK3 gene on chromosome 19q13 may be associated with aggressive and high-grade PC. Future prospectively designed, case-case GWAS are needed to identify additional SNPs associated with PC aggressiveness. (shrink)

On Sikh ethics; includes brief biographies of Sikh religious leaders.

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Method in Ancient PhilosophyDavid K. GliddenJyl Gentzler, editor. Method in Ancient Philosophy. Oxford: Clarendon Press, 1998. Pp. viii + 398. Cloth, $72.00.The fifteen papers in this collection constitute revisions of conference proceedings and reflect the varied interests of participants. The ensemble exhibits a thoroughly modern methodology. Whatever and however various ancient methods of philosophy may have been, in Anglo-American scholarship it is standard practice to first address established (...) scholarly interpretations as the primary entry point to critical discussionóoften displacing antiquity with a critical vocabulary of philosophical modernity. Scholars may come to understand each other better, but at the risk of asking the wrong questions or sacrificing ancient texts themselves as mere means of producing papers.Most scholars are progressives. They believe philosophy has advanced past the comparatively primitive wisdom of antiquity, and so such scholars feel perfectly entitled to make better sense of ancient texts, by patiently explaining what the ancients would have meant had they only been able to get it right. There are, of course, exceptions. And some papers in this collection suggest deeper faith in our philosophic fathers. So, the battle between the ancients and the moderns is joined once more, between those who would adorn their papers with footnotes for their peers and those who would attempt more anthropological an inquiry into ancient philosophic practices.Ian Mueller and Robert Bolton each address the same passage in Plato's Phaedo, both beginning with an article from Vlastos, first published in 1969. Mueller thoughtfully explores three different yet related accounts of what we might call scientific method in explaining Plato's views on natural change. Bolton wonders whether scholars are asking the wrong questions. Patricia Curd attempts a progressivist account of Eleatic thought, notwithstanding her recognition of the paucity of ancient sources. Complete with elaborately numbered sentences, Gail Fine focuses primarily on Burnyeat (1976) on Plato on Protagoras. Constance Meinwald presents a rather near-sighted account of two passages in the Philebus that employ the peras-apeiron distinction, with a view toward Plato's allegedly modernist mathematization of understanding. Lesley Brown revisits five pages of the Sophist that were hotly debated in the 1960s. With charity and elegance, she offers several plausible solutions to puzzles posed by previous scholars. Sometimes time smoothes over differences.A. A. Long's essay on Plato's presentation of Socrates in the Theaetetus might appear more philosophically anthropological. Yet Long reveals progressive sympathies, suggesting that Plato dispatches Socrates in the Theaetetus, so as to prepare the way for a more rigorously academic form of philosophizing, such as that exhibited in the Sophist. [End Page 111] In this way, Long speculates, Plato abandoned practical ethics for the academic life of research, so familiar to university professors and conference participants. It might be hard to square such speculation with Plato's Laws and the reception of Plato's writings among his own contemporaries. Still, Socrates' shifting role in Plato's dialogues is well worth pondering.By comparison, T. H. Irwin's contribution is wonderfully old-fashioned. His paper addresses the background knowledge to be presumed by ancient readers of Plato's dialogues and how that knowledge is artfully put to use in Plato's depiction of Socrates' reflections on the unity of virtue. By speculating on Plato's relation to his ancient readers, Irwin displaces many modernist preoccupations, though not without himself falling victim to that peculiar scholarly obsession of dating Plato's dialogues by their doctrines.With characteristic conservatism, Gisela Striker cautions scholars not to over-read Aristotle's Prior Analytics. While that extraordinary work may have deep implications for the history of formal logic, it probably was instead intended to be part of a general account of argument. In a similar vein, Charlotte Witt attempts to rescue Aristotle from scholars who would delimit Aristotle's multifarious uses of the "for the sake of" explanation, which altogether pervade his metaphysics, physics, biology and ethics. Yet, Witt soon finds herself competing in a contest over interpretive distinctions, a sport that will certainly never capture Aristotle's own authorial intentions.Facing another mass of scholarship, in this case on Aristotle's dialectic, C. D. C. Reeve sensibly attempts to... (shrink)

Study of rationalism in Urdu literature.

Context: Although second-order cybernetics was proposed as a new way of cybernetic investigations around 1970, its general status and its modus operandi are still far from obvious. Problem: We want to provide a new perspective on the scope and the currently available potential of second-order cybernetics within today’s science landscapes. Method: We invited a group of scholars who have produced foundational work on second-order cybernetics in recent years, and organized an open call for new approaches to second-order cybernetics. The accepted (...) contributions are discussed and mapped. We also investigate the relations between second-order cybernetics and second-order science. Results: We present a coherent outlook on the scope of second-order cybernetics today, identify a general methodology of science and show that second-order cybernetics can be used in a large number of disciplines that go well beyond purely scientific domains. These results are based on a new epistemic mode “from within,” which can be traced back directly to von Foerster. We also arrived at the conclusion that from its early years onwards second-order cybernetics was developed in two different ways, so that second-order cybernetics and second-order science operate in different domains. Implications: Both the coherent perspective of the scope of second-order cybernetics with a new five-part agenda and the outline for a general methodology of science based on a new epistemic mode that was created within and for second-order cybernetics demonstrate the growing importance of reflexivity in science, which, so far, has not been widely recognized. (shrink)

Purpose: Several accounts like Ernst von Glasersfeld's Who Conceives of Society? (2008) locate empirical research in the social sciences and radical constructivism in almost parallel universes. The main purpose of this paper is to argue for more inter-active relations and to stress the importance of establishing weak, medium and strong ties between radical constructivism and empirical social research in general. Findings: The article shows that that weak, medium and strong ties between radical constructivism and empirical research in the social sciences (...) can be established. Moreover, these weak, medium and strong ties play a crucial role for increasing and maintaining the relevance of radical constructivism within the social sciences and for contributing to the viability of radical constructivism in the long run. Implications: The most important consequence for radical constructivism lies in a new research agenda. In the course of this article weak, medium and strong ties to empirical research have been specified specifically and exclusively for the social sciences. But these specific links cannot be simply generalized or transferred to other disciplinary fields outside the social sciences. Since interactive links between radical constructivism and empirical research are currently missing in practically all disciplines, these weak, medium and strong links, as a new RC-agenda, have to be developed separately for each major scientific research arena. (shrink)

Open peer commentary on the target article “From Objects to Processes: A Proposal to Rewrite Radical Constructivism” by Siegfried J. Schmidt. Upshot: The subtitle of “An Austrian Contribution” emphasizes a basic distinction between German and Austrian traditions in the philosophy of fields of science. In S. J. Schmidt’s genuinely German way of writing, one can observe a high emphasis on terminology and a specific arena of heavy philosophical problems that have to be solved in a strictly philosophical manner, whereas the (...) Austrian tradition places its importance on scientific progress, especially in the natural sciences, and on the clarifying, mediating, and self-reflecting role of philosophy within the overall context of scientific evolution. (shrink)

Open peer commentary on the target article “Who Conceives of Society?” by Ernst von Glasersfeld. Excerpt: I will make the point that radical constructivism von Glasersfeld style unnecessarily plays only a passive or an inactive role. Quite obviously, I want to demonstrate that there is life for radical constructivism outside its seemingly irrelevant function in empirical social research and that it is possible to develop radical constructivism in designs with tangible consequences and effects for the cognitive routines in the social (...) sciences. In short, it is conceivable, despite “Who Conceives of Society?”, that radical constructivism matters. (shrink)

Translation and interpretation of selected Hadith on Islamic ethics and coduct.

This book uses the writings of Syed Alam Khundmiri to look at issues such as: Islamic traditionalism in the context of meodernization; Islamic theology and politics; and Western and Indian notions of secularism.

Purpose: The article pursues three aims. First, it intends to differentiate between two different approaches for knowledge studies, namely an empirical and a normative mode. In a second move, two different epistemologies in the work of Ernst von Glasersfeld will be introduced under the labels of “Epistemology I” and “Epistemology II.” Epistemology I relates to empirical research, Epistemology II is normative in nature. Third, the article makes the point that while Ernst von Glasersfeld’s Epistemology II has already been presented in (...) a finite and mature form, his empirical analysis of cognitive processes still provides a rich pool of tools and designs that should be further developed and advanced in the years and decades ahead. Method: The article is analytical in nature, identifying the different building blocks and relational networks of von Glasersfeld’s two epistemologies. By this, the article intends to contribute to a further advancement of von Glasersfeld’s Epistemology I. Results: The main finding lies in recognizing the radical and innovative elements of von Glasersfeld’s Epistemology I and on the still-challenging research designs of Epistemology I. (shrink)

In this fascinating study van der Meulen undertakes to show that the Hegelian view of spirit and history is untenable. The critique is extended to Marx's theories. Throughout the work the Hegelian views are contrasted with the more dualistic position of Kant.--K. H.

Open peer commentary on the article “Observing Environments” by Hugo F. Alrøe & Egon Noe. Upshot: The following remarks elaborate on the basic concepts of observation and environment. Some extensions are suggested, mainly from the perspective of Luhmann’s theory of social systems. Especially, the concept of structural couplings is given more emphasis, not least because of its relevance to the sustainability debate.

Context: The journal Constructivist Foundations celebrates ten years of publishing articles on constructivist approaches, in particular radical constructivism. Problem: In order to preserve the sustainability of radical constructivism and regain its appeal to new generations of researchers, we set up a new course of action for and with the radical constructivist community to study its innovative potential. This new avenue is “second-order science.” Method: We specify two motivations of second-order science, i.e., the inclusion of the observer, and self-reflexivity that allows (...) second-order science to operate on the products of normal or first-order science. Also, we present a short overview of the contributions that we have collected for this inaugural issue on second-order science. Results: These six initial contributions demonstrate the potential of the new set of approaches to second-order science across several disciplines. Implications: Second-order science is believed to be a cogent concept in the evolution of science, leading to a new wave of innovations, novel experiments and a much closer relationship with current research in the cognitive neurosciences in particular, and with evolutionary and complexity theories in general. (shrink)

Study on logic from an Islamic perspective; includes study on presentation of teachings of Islam according to science and nature.

On the eminence and dignity of parents; in the light of Koran and Hadith (Islamic traditions).

On Sikh doctrines inunciated by Guru Nanak.

Study of the religious and philosophical views of Sir Muḥammad Iqbal, 1877-1938.

Stressing the importance of Kant's revisions in the second edition of the Critique, the author advances the thesis that being-in-itself is determinable as a spontaneity which determines the manifold in time. A well-written, stimulating, and highly speculative study of time and spontaneity in Kant's thought.--K. H.

In spite of, or perhaps because of the wealth of material found in this book, it makes a rather arid impression. One wishes for more structure and a clearer statement of the author's own position. Kainz professes to "have patterned his aesthetics on the philosophical personalism of William Stern"; but other influences, such as that of phenomenology and Gestalt psychology, are also prominent. The great variety of views mentioned and discussed gives this book considerable value as a bibliographical guide to (...) recent literature on aesthetics in German. Schueller's introduction is helpful in placing Kainz's position in a larger context.--K. H. (shrink)

This brief study of the temptations of Jesus shows the author to be a powerful preacher. An extended sermon on man, as standing between the temptation of the devil and an obedience to God.--K. H.

Himmerich gives a thorough statement of Plotinus' anthropology, placed in the wider context of his philosophy interpreted theistically. The work is concerned to show that the Plotinian image of man, passing from the active life of youth to the wisdom of old age, is still viable today. Clear and intelligent.--K. H.

By means of an analysis of Nicolai Hartmann's thought, the author attempts to show that his and, indeed, all ontological projects are unable to develop criteria showing why a certain ontology should be preferred over another. The reason for this is sought in the "gnoseo-ontological circle"--the fact that all attempts to state such criteria already imply a commitment to a certain ontology. It is impossible to appeal beyond this circle. Consequently, the only remaining choice is between skepticism and the path (...) which Heidegger has pointed out, a path which leads beyond all ontology. Bold though it is, the argument is developed with great clarity.--K. H. (shrink)

Context: Many recent research areas such as human cognition and quantum physics call the observer-independence of traditional science into question. Also, there is a growing need for self-reflexivity in science, i.e., a science that reflects on its own outcomes and products. Problem: We introduce the concept of second-order science that is based on the operation of re-entry. Our goal is to provide an overview of this largely unexplored science domain and of potential approaches in second-order fields. Method: We provide the (...) necessary conceptual groundwork for explorations in second-order science, in which we discuss the differences between first- and second-order science and where we present a roadmap for second-order science. The article operates mainly with conceptual differentiations such as the separation between three seemingly identical concepts such as Science II, Science 2.0 and second-order science. Results: Compared with first-order science, the potential of second-order science lies in 1. higher levels of novelty and innovations, 2. higher levels of robustness and 3. wider integration as well as higher generality. As first-order science advances, second-order science, with re-entry as its basic operation, provides three vital functions for first-order science, namely a rich source of novelty and innovation, the necessary quality control and greater integration and generality. Implications: Second-order science should be viewed as a major expansion of traditional scientific fields and as a scientific breakthrough towards a new wave of innovative research. Constructivist content: Second-order science has strong ties with radical constructivism, which can be qualified as the most important root/origin of second-order science. Moreover, it will be argued that a new form of cybernetics is needed to cope with the new problems and challenges of second-order science. (shrink)

In this slender volume in The Humanist Library series, Nielsen not only argues for the independence of morality from religion, but as well outlines a normative theory as an alternative to religious [[sic]] morality. The basis of religious morality is the belief that God is all good, and thus we should do what he commands. In response to this, Nielsen elaborates Plato’s argument that morality cannot be based upon religious belief. However one understands the claim "God is good," i.e., whether (...) it is analytic or not, understanding "good" is logically presupposed for one to be able to grasp the meaning or truth of the claim. It is more correct to say that religion is based upon morality since the basis of religious belief is that there is a being worthy of worship, and this conclusion must rest upon autonomous moral insight. The remainder of the book is concerned with two themes involving the competing claims of secular and religious morality. The first is that only the religious perspective provides an adequate account of man’s origin and destiny, and thus the perspective from which one can find happiness and fulfillment. In response, Nielsen invokes "all the old as well as some new objections to religion" as the perspective which provides a true account of the nature of things. Moreover, there is no reason to believe that only religious persons find happiness and meaning in life. The second claim of religious morality is that it alone can provide a satisfactory basis for moral theory. Secular moral theory can provide only conventional relativism. In reply, Nielsen outlines and defends a normative theory of the consequentialist variety. The last part of the book is a general defense of consequential ethical theories against Anscombe-like objections which are associated with "religious absolutism" for reasons not specified.—T.K.H. (shrink)

Not only does Klemmt succeed in showing the importance of Reinhold as a key figure between Kant and Fichte, but he also establishes the originality of his work; especially interesting is his analysis of Reinhold's philosophy of consciousness, which anticipated important tenets of phenomenology. To regard this study as merely historical would be a mistake, for it is an impressive attempt to investigate some of the fundamental principles of theoretical philosophy.--K. H.

Bergler argues for the all-pervasiveness of a repressed psychic masochism. The argument is supported by a great wealth of clinical material. Nevertheless it seems doubtful whether this quite justifies the sweeping thesis. The writing is somewhat loose and the tone of Bergler's attack on his critics unfortunate.--K. H.